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. 2022 Aug 10;608(7922):360–367. doi: 10.1038/s41586-022-05023-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a,b, Benign lymph node with distinct histological features and gene expression heterogeneity (b) harbouring no detected copy number alterations (a). Gene expression clusters were determined by UMAP analysis in b. c,d, Skin containing SCC (clone A, red) as well as benign squamous epithelium (clone C, yellow). A subset of somatic events visualized in cancer clone A are also detected in adjacent benign epithelial clone C. d, FISH validation of the siCNV encompassing EHD2 on chromosome 19q (arrowhead in c). e,f, Monoclonal childhood medulloblastoma. siCNVs on chromosomes 3 and 9 (e) were corroborated by copy number calls from WGS (f, lower right). g, Clone distribution for each tissue type. Circle area corresponds to the number of spots per clone. Results from ductal breast cancer and glioblastoma are available in Extended Data Fig. 11.