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. 2022 Aug 10;608(7922):360–367. doi: 10.1038/s41586-022-05023-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 4 — a, Visual selection of benign epithelial spots harbouring the least amount of inferred copy number variations, as outlined by the black box bounding box. Arrows identify dendrogram nodes corresponding to barcoded spots within the box. b, InferCNV output of the dendrogram nodes with numerical identifiers for selection corresponding to Panel a. c, Finalized benign reference set from analysis of epithelial cells in prostate patient 1, section H2_1 (Fig. 3). d, Global spatial inferCNV profiles of the selected benign reference set from panel a, the remainder of the benign not included in the reference set, altered benign (Clone C, Fig. 3), and the other Visium spots with luminal epithelial annotations (PIN, GG1, GG2, GG4, GG4 Cribriform).