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. 2022 Aug 10;608(7922):360–367. doi: 10.1038/s41586-022-05023-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 5 — a, Consensus pathology annotations for tumour spots from sections H2_1, H2_2, and H1_2. b, Clonal groupings of spots (approx. 10-15 cells each) determined by hierarchical clustering. c, Distinct siCNV profile of GG1 tumour focus from organscale prostate patient 1. siCNV profiling of epithelial Visium spots from section H1_2. d, Spot level histology and siCNV clone calls. GG = ISUP Gleason ‘Grade Group’, siCNV = spatial inferCNV.