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. 2022 Aug 11;316:245–253. doi: 10.1016/j.jad.2022.08.017

Table 6.

Comparison of clinically significant symptoms of depression and anxiety in perinatal women during the COVID-19 pandemic versus pre-pandemic studies.

Depression
Pregnant women
Postpartum women
Pre-pandemic
Pandemic
χ2 Pre-pandemic
Pandemic
χ2
Study EPDS ≥13
n (%)
EPDS ≥13
n (%)
Study EPDS ≥13
n (%)
EPDS ≥13
n (%)
Brazil Jacques et al., 2021 504 (16.1) 101 (37.7) 78.70⁎⁎⁎ Filha et al., 2016 3065 (25.7) 282 (47.2) 134.61⁎⁎⁎
Chile Jadresic et al., 1992 8 (7.4)a 85 (49.4) 52.79⁎⁎⁎ Rojas et al., 2018 121 (39.7)a 150 (55.1) 13.82⁎⁎⁎
Cyprus n.a. n.a. 40 (18.2) n.a. n.a. 56 (22.5)
Greece Koutra et al., 2014 73 (16.7) 64 (19.0) 0.71 Chatzi et al., 2011 74 (14.0) 90 (23.9) 14.66⁎⁎⁎
Israel Polachek et al., 2014 22 (24.7)b 75 (34.4) 2.74 Simhi et al., 2019 84 (8.4)a 128 (38.2) 166.92⁎⁎⁎
Portugal Figueiredo and Conde, 2011 49 (19.0)a 298 (39.6) 36.87⁎⁎⁎ Costa et al., 2007 27 (13.7) 188 (28.1) 16.90⁎⁎⁎
Spain Vázquez and Míguez, 2019 133 (23.4)a 153 (43.3) 40.60⁎⁎⁎ Escriba-Aguir and Artazcoz, 2011 48 (11.4) 159 (33.5) 60.93⁎⁎⁎
Turkey Dikmen-Yildiz et al., 2017 262 (27.5)c 261 (32.4) 4.81 Dikmen-Yildiz et al., 2017 219 (25.5) 216 (34.8) 15.03⁎⁎⁎
UK Howard et al., 2018 143 (26.2) 63 (31.7) 2.14 Matijasevich et al., 2009 1393 (10.1) 136 (39.3) 298.71⁎⁎⁎



Anxiety
Pregnant women
Postpartum women
Pre-pandemic
Pandemic
χ2 Pre-pandemic
Pandemic
χ2
Study GAD-7 ≥10 (%) GAD-7 ≥10 (%) Study GAD-7 ≥10 (%) GAD-7 ≥10 (%)
Brazil Pabon et al., 2020 159 (29.9) 92 (34.3) 1.59 Lamus et al., 2021 101 (19.6) 250 (41.9) 63.45⁎⁎⁎
Chile n.a. n.a. 62 (36.0) n.a. n.a. 113 (41.5)
Cyprus n.a. n.a. 30 (13.6) n.a. n.a. 40 (16.1)
Greece n.a. n.a. 51 (15.1) n.a. n.a. 96 (25.5)
Israel n.a. n.a. 33 (15.2) n.a. n.a. 41 (12.3)
Portugal n.a. n.a. 149 (19.8) n.a. n.a. 151 (22.6)
Spain Soto-Balbuena et al., 2018 31 (8.2) 104 (29.5) 56.48⁎⁎⁎ n.a. n.a. 160 (33.7)
Turkey n.a. n.a. 102 (12.7) n.a. n.a. 101 (16.3)
United Kingdom n.a. n.a. 42 (21.1) n.a. n.a. 97 (28.0)

Notes: n.a. = no study available using this instrument; UK = United Kingdom. EPDS = Edinburgh Postnatal Depression Scale; GAD-7 = Generalized Anxiety Disorder Screener. In cases where the pre-pandemic studies used an EPDS cutoff score different than 13, and to enable comparisons with our own data, we recalculated the frequencies and percentages for our pandemic data according to the specific cutoff score used by each of those pre-pandemic studies.

p < .05.

⁎⁎⁎

p < .001.

a

EPDS ≥10.

b

EPDS ≥11.

c

EPDS ≥12.