Figure 2.

Repositioning of subtelomeric genes internally to chromosomal arms reveals their contact in 3D

(A) Contact map of chrA in n = 2 (5 kb-binned). Red arrowheads point at cis contact enrichment between HML, HMR, and TEL. Violet to white color scale reflects high to low contact frequencies as in Figure 1.

(B) Dotted lines indicate locations of the FLO genes both on n = 2 and n = 16 chromosomes. Contact maps of unique FLO-flanking regions in n = 2 and n = 16 (2 kb-binned). y and x axes indicate gene name and the orientation of the unique 10-kb sequences flanking the FLO5′ and-3′ UTRs) in the n = 2 genome. The resulting 20-kb regions adjacent to each gene are underlined by dotted lines.