Table 3.

Correlation of MMP1 expression and OS in hepatocellular carcinoma patients with different clinicopathological factors via Kaplan–Meier plotter.

Clinicopathological factors	Subgroup	Overall survival
		No	Hazard ratio (95% CI)	P value*
T stage	T1	183	2.14 (1.17–3.91)	0.013
	T2	95	1.28 (0.62–2.65)	0.499
	T3	80	1.77 (0.96–3.26)	0.065
	T4	13	0.37 (0.09–1.55)	0.173
N stage	N0	254	1.51 (0.98–2.33)	0.064
	N1	4	NA	NA
M stage	M0	268	1.62 (1.05–2.51)	0.029
	M1	4	NA	NA
Pathologic stage	Stage I	173	2.21 (1.17–4.17)	0.014
	Stage II	87	1.59 (0.72–3.51)	0.251
	Stage III	85	1.78 (0.98–3.22)	0.059
	Stage IV	5	NA	NA
Tumor status	Tumor free	202	1.76 (0.95–3.28)	0.074
	With tumor	153	1.57(1.00–2.46)	0.049
Gender	Male	253	2.23 (1.41–3.52)	0.001
	Female	121	1.31 (0.75–2.28)	0.348
Age	≤ 60	177	2.07 (1.21–3.57)	0.008
	> 60	196	1.61 (1.01–2.56)	0.046
BMI	≤ 25	177	2.14 (1.26–3.63)	0.005
	> 25	160	1.35 (0.78–2.36)	0.284
Residual tumor	R0	327	1.70 (1.16–2.50)	0.006
	R1	17	1.00 (0.21–4.71)	0.996
	R2	1	NA	NA
Histologic grade	G1	55	3.45 (1.26–9.46)	0.016
	G2	178	1.96 (1.15–3.32)	0.013
	G3&G4	136	2.20 (1.21–3.97)	0.009
AFP(ng/ml)	≤ 400	215	2.19 (1.29–3.70)	0.004
	> 400	65	2.14 (0.89–5.12)	0.088
Albumin(g/dl)	< 3 5	69	1.51 (0.64–3.53)	0.347
	≥ 3 5	231	1.86 (1.14–3.03)	0.013
Prothrombin time	≤ 4	208	2.30 (1.30–4.07)	0.004
	> 4	89	0.94 (0.51–1.76)	0.852
Child–Pugh grade	A	219	1.88 (1.11–3.20)	0.019
	B	21	1.83 (0.44–7.58)	0.406
	C	1	NA	NA
Fibrosis ishak score	0	75	1.98 (0.92–4.24)	0.079
	1/2	31	0.79 (0.21–2.98)	0.731
	3/4	28	1.70 (0.30–9.61)	0.551
	5/6	81	2.84 (1.07–7.54)	0.036
Vascular invasion	No	208	1.71 (1.02–2.87)	0.041
	Yes	110	1.20 (0.62–2.33)	0.594

OS overall survival, CI confidence interval, NA not available data. *Compared with each subgroup based on MMP1 expression of 0–50% vs 50–100%. p < 0.05 means statistically significant (highlighted in bold).