Table 5.
The univariate and multivariate analysis for the DSS.
| Characteristics | Total(N) | Univariate analysis | Multivariate analysis | |||
|---|---|---|---|---|---|---|
| Hazard ratio (95% CI) | P value* | Hazard ratio (95% CI) | P value* | |||
| T stage | T1&T2 | 272 | Reference | NA | NA | |
| T3&T4 | 90 | 3.639 (2.328–5.688) | < 0.001 | 1.075 (0.117–9.839) | 0.949 | |
| N stage | N0 | 249 | Reference | |||
| N1 | 4 | 3.612 (0.870–14.991) | 0.077 | |||
| M stage | M0 | 265 | Reference | NA | NA | |
| M1 | 3 | 5.166 (1.246–21.430) | 0.024 | 2.550 (0.458–14.183) | 0.285 | |
| Pathologic stage | Stage I&II | 254 | Reference | NA | NA | |
| Stage III&IV | 87 | 3.803 (2.342–6.176) | < 0.001 | 2.022 (0.219–18.673) | 0.535 | |
| Tumor status | Tumor free | 202 | Reference | |||
| With tumor | 152 | 775,790,759.389 (0.000-NA) | 0.994 | |||
| Gender | Male | 247 | Reference | |||
| Female | 118 | 1.230 (0.780–1.937) | 0.373 | |||
| Age | ≤ 60 | 174 | Reference | |||
| > 60 | 191 | 0.846 (0.543–1.317) | 0.458 | |||
| BMI | ≤ 25 | 175 | Reference | |||
| > 25 | 154 | 0.826 (0.512–1.330) | 0.431 | |||
| Residual tumor | R0 | 320 | Reference | |||
| R1&2 | 17 | 1.678 (0.728–3.870) | 0.224 | |||
| Histologic grade | G1 | 55 | Reference | |||
| G2 | 172 | 1.177 (0.599–2.314) | 0.636 | |||
| G3&G4 | 133 | 1.228 (0.613–2.462) | 0.562 | |||
| AFP(ng/ml) | ≤ 400 | 214 | Reference | |||
| > 400 | 61 | 0.867 (0.450–1.668) | 0.668 | |||
| Albumin(g/dl) | < 3 5 | 67 | Reference | |||
| ≥ 3 5 | 227 | 1.148 (0.586–2.250) | 0.687 | |||
| Prothrombin time | ≤ 4 | 203 | Reference | NA | NA | |
| > 4 | 87 | 1.778 (1.054–2.999) | 0.031 | 1.447 (0.564–3.716) | 0.442 | |
| Child–Pugh grade | A | 214 | Reference | NA | NA | |
| B | 20 | 2.439 (1.011–5.885) | 0.047 | 3.667 (1.135–11.845) | 0.030 | |
| C | 1 | 3.584 (0.484–26.513) | 0.211 | |||
| Fibrosis ishak score | 0 | 73 | Reference | |||
| 1/2 | 31 | 1.523 (0.639–3.630) | 0.342 | |||
| 3/4 | 28 | 0.632 (0.183–2.191) | 0.470 | |||
| 5/6 | 78 | 0.788 (0.363–1.708) | 0.545 | |||
| Vascular invasion | No | 204 | Reference | |||
| Yes | 105 | 1.277 (0.707–2.306) | 0.418 | |||
| MMP1 | 365 | 1.389 (1.188–1.624) | < 0.001 | 1.424 (1.020–1.987) | 0.038 | |
DSS disease specific survival, CI confidence interval, NA reference group or could not be evaluated. *Compared with each group (Log-Rank test or Omnibus test for univariate, Cox regression analysis with adjusted hazard for multivariate). p < 0.05 means statistically significant (highlighted in bold).