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. 2022 Aug 10;11(1):47. doi: 10.1038/s41389-022-00422-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A KM plots of recurrence-free survival in ER-positive (n = 2354) and ER-negative (n = 1080) breast cancer patients according to Spin90 level. Outlier data were removed for quality control. HR hazard ratio. B Representative IHC images showing expression of SPIN90 (green) and the epithelial cell marker E-cadherin (red) in breast cancers and paired normal stroma from ER-positive (n = 29) and ER-negative (n = 11) samples in a tumor microarray (BR804b). The white arrows indicate stromal fibroblasts. The graph shows the relative intensity score of SPIN90 in stroma as follows: 0 = negative, 1 = weak, 2 = moderate, 3 = strong. The images were scanned with an Olympus research slide scanner and analyzed using the Olympus cellSens and ImageJ software packages. Scale bar, 50 μm. All data are presented as mean ± standard deviation. *p ≤ 0.05; ***p ≤ 0.001 (Student’s t-test).