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. 2022 Aug 10;13:4684. doi: 10.1038/s41467-022-32348-3

Fig. 1. Waved 2 mice developed less metabolic derangement in diet induced obesity.

Fig. 1

Waved 2 mice with intrinsic EGFR tyrosine kinase deficiency and WT mice were fed the HFD for 12 weeks. A, B Both male and female Waved 2 mice had lower body weight (Male: n = 6 and 10; female: n = 5) A and body weight gain (Male: n = 6 and 10; female: n = 5) B. C Both male and female Waved 2 mice had less visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) mass compared to WT mice (Male: n = 6 and 10; female: n = 4 and 5). D, E Both male and female Waved 2 mice had lower fasting blood glucose (Male: n = 5 and 7; female: n = 5) D and HbA1c (Male: n = 5 and 7; female: n = 3) E. N = 5 and 7. F, G Male Waved 2 mice had improved glucose tolerance (n = 6 and 9) F and insulin tolerance (n = 4) G. Data are means ± SEM, *P < 0.05, **P < 0.01, ***P < 0.001, analyzed using 2 tailed Student’s t test for A, B, D, and E; 2-way ANOVA followed by Bonferroni’s post hoc test for C; 2 tailed Student’s t test and 2-way ANOVA followed by Tukey’s post hoc test for F; and 2-way ANOVA followed by Tukey’s post hoc test for G.