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. 2022 Aug 10;13:4684. doi: 10.1038/s41467-022-32348-3

Fig. 8. Mice with myeloid EGFR deletion had decreased ATM proliferation in diet-induced obesity.

Fig. 8

WT and MΦ EGFR−/− mice were fed the HFD for 6 or 12 weeks. A The significantly increased proliferating rate of ATMs in EF (EdU positive cells) seen in WT mice at 6 weeks was markedly attenuated in MΦ EGFR−/− mice. N = 4 and 5 and 6. B, C A decreased rate of proliferation in MΦ EGFR−/− mice at 6 weeks was also indicated by decreased EdU and CD68-double positive cells (n = 5 and 9) B and Ki67 and CD68-double positive cells (n = 5) C. Scale bar = 100 μm. Data are means ± SEM, **P < 0.01, ***P < 0.001, analyzed using 2-way ANOVA followed by Bonferroni’s post hoc test for A and B, and 2 tailed Student’s t test for C.