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. 2022 Aug 10;12:13609. doi: 10.1038/s41598-022-17887-5

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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11q23.1 trans-eQTL targets are correlated with the expression of POU2AF2, but not COLCA1 or COLCA2 in pseudo-bulked scRNASeq. (a) Hierachical clustering of complete distances between pairwise correlations of 11q23.1 nominal trans-eQTL targets pseudo-bulked expression (p < 0.01, n = 273) in 32,361 healthy colonic epithelial scRNAseq²². (b) Weighted Gene Co-expression Network Analysis (WGCNA²⁰, identified module trait relationships. Pearson correlations shown above Benjamini-Hochberg⁴⁵ corrected p-values in brackets. (c) Gene Set Enrichment Analysis (GSEA) of 11q23.1 trans-eQTL targets (FDR < 0.05) in blue module genes, ranked by their module membership. (d) Kamadakawai network of Blue module relatedness (adjacency > 0.3). Red nodes indicate FDR < 0.05 trans-eQTL target of 11q23.1.