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. 2022 Aug 10;12:13609. doi: 10.1038/s41598-022-17887-5

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Several 11q23.1 trans-eQTL targets comprise POU2AF2-correlated network in tuft-like cluster only. (a) Relative (z-score) expression of blue module hub genes from Fig. 1d (MM > 0.7, kIM > 0.7, adj > 0.3). Robustness assessed by 10,000 permutations: p = 0.055. (b) Module trait matrix of gene modules identified by WGCNA within pseudo-bulked expression from cluster 11. Only modules exhibiting a correlation with a covariate (FDR < 0.1) are shown. Total number of modules = 20. (c) Correlation of Gene Significance (GS) and Module Membership (MM) of genes in the black module from (b). 11q23.1 trans-eQTL targets are highlighted. 11q23.1 trans-eQTL targets with GS.POU2AF2 > 0.5 and MM.black > 0.5 (red) were used as the auxiliary module. (d) Preservation of correlations between auxiliary module genes with the module eigengene (ME) and equivalent values in cluster 11. Dashed line indicates nominal significance threshold (p = 0.05). (e) Average MM of genes within the auxiliary module across clusters. (f) Pairwise Pearson correlations (p < 0.05) between the pseudo-bulked expression of auxiliary module genes across clusters. Cluster number in upper right of each facet. Cluster 4 and 8 exhibited no significant (p < 0.05) correlations and so are not plotted.