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. 2022 Aug 10;12:13609. doi: 10.1038/s41598-022-17887-5

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Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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11q23.1 trans-eQTL target expression is associated with the abundance of tuft cell-like cluster. (a) Linear modelling of pseudo-bulked POU2AF2 expression and cluster 11 abundance. (b) Volcano plot of linear model result on pseudo-bulked expression of all 14,843 genes. Significantly associated 11q23.1 trans-eQTLs (logFC > 1, FDR < 0.05) highlighted. (c) GSEA of 11q23.1 trans-eQTLs (FDR < 0.05) in (b), ranked by logFC. (d) Differential abundance of neighbourhoods in the ‘Low’ blue hub gene group compared to ‘High’. Neighbourhoods were identified using miloR²⁶ and grouped by cluster. Only neighbourhoods with major cluster proportion > 0.8 are plotted and only significant neighbourhoods (Spatial FDR < 0.01) are coloured by their logFC (red = down, blue = up). No neighbourhoods from cluster 10 were comprised of major proportion > 0.8.