Table 2.
Settings of dose parameters used for proton optimization and planning.
| Spot filtering settings | |||
|---|---|---|---|
| Iterations before spit filtering | 40 | ||
| Min spot meterset (MU/fx) | 0.135 | ||
| Max spot meterset (MU/fx) | 42 | ||
| Meterset limit margin (%) | 5 | ||
| Proton plan optimization | |||
| ROI | Description | Weight | |
| PTV_TMI | Min dose 1,100 cGy (RBE) | 250 | |
| PTV_TMI | Max dose 1,440 cGy (RBE) | 1,000 | |
| Airway | Max dose 650 cGy (RBE) | 100 | |
| Bladder | Max dose 650 cGy (RBE) | 100 | |
| Bowel | Max dose 650 cGy (RBE) | 100 | |
| Brain | Max dose 650 cGy (RBE) | 100 | |
| Esophagus | Max dose 650 cGy (RBE) | 100 | |
| Heart | Max dose 400 cGy (RBE) | 100 | |
| LT optic nerve | Max dose 650 cGy (RBE) | 100 | |
| LT orbit | Max dose 650 cGy (RBE) | 100 | |
| Parotids | Max dose 650 cGy (RBE) | 100 | |
| RT optic nerve | Max dose 650 cGy (RBE) | 100 | |
| RT orbit | Max dose 650 cGy (RBE) | 100 | |
| Spleen | Min dose 1,200 cGy (RBE) | 100 | |
| Stomach | Max dose 650 cGy (RBE) | 100 | |
| Thyroid | Max dose 650 cGy (RBE) | 100 | |
| Total lung | Max dose 650 cGy (RBE) | 250 | |
| Total kidneys | Max dose 750 cGy (RBE) | 100 | |
ROI, region of interest; PTV, planning target volume; TMI, total marrow irradiation; RBE, relative biological effectiveness.