TABLE 1.
Baseline demographic and laboratory characteristics of participants.a
| Variables | Sitagliptin group (n = 44) | Placebo group (n = 32) | P-valueb | |
| Demographic data | ||||
| Sex; n (%) | 0.99 | |||
| Male | 33 (75) | 24 (75) | ||
| Female | 11 (25) | 8 (25) | ||
| Age (years) | 45.0 (36.8, 53.2) | 39.0 (33.8, 44.2) | 0.03 | |
| Height | 168.0 (163.0, 177.2) | 170.5 (162.0, 179.2) | 0.59 | |
| Weight | 84.0 (76.8, 92.0) | 82.5 (74.5, 94.1) | 0.65 | |
| BMI (kg/m2) | 29.6 (26.5, 32.7) | 28.8 (26.4, 31.4) | 0.67 | |
| Metabolic factors | ||||
| BMI categories; n (%) | 0.46 | |||
| Normal | 6 (13.6) | 3 (9.4) | ||
| Overweight | 18 (40.9) | 18 (56.2) | ||
| Obese | 20 (45.5) | 11 (34.4) | ||
| FBS (mg/dl) | 101.5 (96.8, 114.0) | 107.0 (98.0, 112.2) | 0.97 | |
| Insulin (mU/L) | 13.3 (9.6, 18.4) | 14.4 (10.7, 17.8) | 0.48 | |
| HOMA-IR | 3.5 (2.4, 4.7) | 3.8 (2.6, 4.6) | 0.44 | |
| Serum lipid levels | ||||
| Total cholesterol (mg/dl) | 189.0 (164.8, 221.8) | 201.0 (174.2, 238.2) | 0.60 | |
| LDL-cholesterol (mg/dl) | 121.0 (110.0, 137.2) | 125.0 (111.5, 137.0) | 0.86 | |
| HDL-cholesterol (mg/dl) | 40.5 (33.8, 45.2) | 42.0 (37.0, 44.0) | 0.45 | |
| Triglyceride (mg/dl) | 145.5 (109.8, 201.2) | 149.0 (106.0, 222.8) | 0.88 | |
| Serum biochemical levels | ||||
| ALT (IU/L) | 44.0 (34.5, 70.0) | 38.0 (33.0, 56.2) | 0.34 | |
| AST (IU/L) | 35.5 (28.0, 49.2) | 31.0 (26.8, 41.2) | 0.14 | |
| GGT (IU/L) | 43.5 (36.5, 55.2) | 40.5 (24.0, 51.2) | 0.06 | |
| ALKP (IU/L) | 201.0 (157.5, 230.5) | 175.5 (159.8, 214.2) | 0.37 | |
| Ferritin (μg/l) | 108.5 (37.5, 172.0) | 95.0 (47.8, 217.2) | 0.92 | |
| Liver histology | ||||
| Ultrasound; n (%) | 0.77 | |||
| Grade 1 | 10 (23) | 9 (28) | ||
| Grade 2 | 14 (32) | 8 (25) | ||
| Grade 3 | 20 (45) | 15 (47) | ||
| Fibrosis score (kPa) | 6.2 (6.0, 7.3) | 6.0 (5.0, 6.9) | 0.045 | |
aMedian (IQR); n (%).
bWilcoxon rank-sum test; Pearson’s Chi-squared test; Fisher’s exact test.
BMI, body mass index; FBS, fasting blood sugar; HOMA-IR, homeostasis model of insulin resistance; LDL, low-density lipoprotein; HDL, high-density lipoprotein; ALT, alanine aminotransferase; AST, aspartate aminotransferase; GGT, gamma-glutamyltransferase. Statistically significant results are reported in bold.