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. 2022 Jul 28;13:938785. doi: 10.3389/fimmu.2022.938785

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Copyright © 2022 Yoshizaki, Fukasawa, Ebata, Yoshizaki-Ogawa and Sato

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Antigen-specific effects of Breg cells. When Breg cell progenitors encounter autoantigens, they differentiate and produce IL-10. Thus, Breg cells suppress excessive immune responses in an antigen-specific manner.