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. 2022 Jul 28;13:897992. doi: 10.3389/fmicb.2022.897992

Figure 3.

Figure 3

Gut microbiota of healthy older people increase the severity of SAP in mice in the early stage. (A) Mouse model of severe acute pancreatitis. (B) Serum amylase levels are significantly increased in the old group (n = 19) compared to the young group (n = 16). (C) Serum IL-6 levels are significantly increased in the old group (n = 14) compared to the young group (n = 12). (D) Representative hematoxylin and eosin staining of pancreatic tissue. (E) Histopathological scoring of pancreatic damage (n = 5 per group). (F) Heatmap of the CFU (log2) of blood and MLN (n = 6 per group). (G) Frequency of culture positivity in blood and MLN (n = 6 per group). CFU (n = 6 per group) in the blood (H) and MLN (I). (J) Expression of tight junction genes ZO-1 in the duodenum, ileum, and colon of the young group (n = 5) versus the old group (n = 5). (K) Expression of tight junction genes OCCULDIN in the duodenum, ileum, and colon of the young group (n = 5) versus the old group (n = 5). *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, ns, no significant difference.