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. 2022 Jul 28;13:897992. doi: 10.3389/fmicb.2022.897992

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Copyright © 2022 Jing, Chang, Xu, Wang, Wu, Huang, Wang and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Mouse model of severe acute pancreatitis. (B) Serum amylase levels are significantly increased in the old group (n = 9) compared to the young group (n = 10). (C) Serum IL-6 levels are significantly increased in the old group (n = 8) compared to the young group (n = 8). (D) Pancreatic and extra pancreatic fat necrosis in mice in the old group on day 4. (E) Serum CRP levels are significantly increased in the old group (n = 8) compared to the young group (n = 8). (F) Heatmap of the CFU(log2) of blood and MLN (n = 8). (G) Frequency of culture positivity in blood and MLN (n = 8 per group). CFU (n = 8 per group) in the blood (H) and MLN (I). ^*p < 0.05, ^**p < 0.01, ^***p < 0.001, ^****p < 0.0001, ns, no significant difference.