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. 2022 Jul 28;9:931293. doi: 10.3389/fmed.2022.931293

FIGURE 2.

FIGURE 2

Protection from IRI requires enzymatic activity of ilofotase alfa. Male WT mice received ilofotase alfa (recAP, 2,000 U/kg, i.v.) or an equivalent dose (based on calculated mg/kg) of a catalytically inactive mutant recAP (mut-recAP) 1 h before 26 min bilateral kidney ischemia and 24 h of reperfusion. (A) Plasma creatinine. (B) Representative histology of outer medulla from H&E-stained sections. Veh, vehicle. Scale bar: 100 μm. Error bars represent mean ± SEM. ****P < 0.0001 by one-way ANOVA. n = 4–10.