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. 2022 Jul 28;9:931293. doi: 10.3389/fmed.2022.931293

FIGURE 3.

FIGURE 3

ZM241,385, an adenosine A2A receptor antagonist, reverses the protective effect of ilofotase alfa in male WT mice. WT mice received vehicle (for recAP) or ilofotase alfa (recAP, 2,000 U/kg, i.v.) 1 h before 26 min bilateral kidney ischemia and 24 h of reperfusion. ZM241,385 (ZM) was administered (sc) immediately before ilofotase alfa (recAP, 2,000 U/kg, i.v.). (A) Plasma creatinine was measured at 24 h. Plasma creatinine was not significantly different in control groups receiving vehicle for recAP (Veh; 1.46 ± 0.22) vs. vehicle for ZM (1.53 ± 0.06) (not shown in figure). Error bars represent mean ± SEM. (B) Representative histology of outer medulla from H&E-stained sections. Scale bar: 100 μm. ***P < 0.001 by one-way ANOVA. Vehicle vs. recAP + ZM. n = 4–6.