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Therapeutic ilofotase alfa protects WT mouse kidneys from injury. Male WT mice received ilofotase alfa (recAP, 2,000 U/kg) 1 h before or 0.5, 1, or 4 h after 26 min bilateral kidney ischemia; kidneys were allowed to reperfuse for 24 h. Control mice were subjected to sham surgery. Plasma creatinine was measured at 24 h. Error bars represent mean ± SEM. **P < 0.01; ****P < 0.001 by one-way ANOVA. n = 4–10.
