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. 2022 Jul 28;9:931293. doi: 10.3389/fmed.2022.931293

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Copyright © 2022 Rosin, Hall, Zheng, Huang, Campos-Bilderback, Sandoval, Bree, Beaumont, Miller, Larsen, Hariri, Kaila, Encarnacion, Gale, van Elsas, Molitoris and Okusa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ilofotase alfa ameliorates kidney injury in rats when administered therapeutically after IRI in the setting of AKI on a background of CKD. (A) Timeline for experiments. (B) GFR in male rats with unilateral nephrectomy (Uni-NX) and sham unilateral ischemia (open circles) and with Uni-NX and unilateral IRI on days 1 and 28 (filled squares). GFR, calculated from 24-h urinary creatinine clearance. (C) Plasma creatinine in CKD rats (after periods of 45, 40, and 30 min of ischemia on days 1, 28, and 56, respectively) at baseline [after randomization to vehicle (V, stars) and recAP (filled squares) groups] and 1, 2, 3, and 7 days later. Open circles, sham controls (Uni-NX and sham unilateral ischemia). n = 4 (sham) and 5 (treatment groups). All values are expressed as mean ± SD. *P < 0.01.