Figure 6.
A summary of the key discoveries regarding adenosine-targeted epitranscriptomic alterations in atherosclerosis and arteriosclerosis to date
Red upward arrows indicate upregulated expression, red horizontal arrows indicate activation, blue downward arrows denote downregulated expression, and blue blunt-end arrows indicate inhibition. . Brown, green, and blue ellipses denote RNAs, proteins, and m6A regulators, respectively. Question mark represents a putative connection based on evidence from other than atherosclerotic tissues. ∗METTL3 has been associated with contrasting functions and expression responses in a model of early atherosclerosis with endothelial oscillatory shear stress. See section “atherosclerosis” for further discussion. The abbreviations are listed within the text.