Figure 7.

Currently known molecular mechanisms involving m⁶A and its key regulators during macrophage inflammation and foam cell formation

Red upward arrows indicate upregulated expression, red horizontal arrows indicate activation, blue downward arrows denote downregulated expression, and blue blunt-end arrows indicate inhibition. Dashed line represents putative relationship. Brown, green, and blue ellipses denote RNAs, proteins, and m⁶A regulators, respectively. Red ellipse denotes phosphorylation. ABCA1, ATP-binding cassette subfamily A member 1; ABCG1, ATP-binding cassette subfamily G member 1; AMPKα, AMP-activated protein kinase α; CXCL10, C-X-C motif chemokine ligand 10; PPAR-γ, peroxisome proliferator-activated receptor γ; SR-A1, scavenger receptor class A member 1; STAT1, signal transducer and activator of transcription 1.