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. 2022 Jul 28;13:915784. doi: 10.3389/fimmu.2022.915784

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Copyright © 2022 Zhou, Zhang and Wang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The visualized PPI network of EP-DEGs for determining the key EP-DEGs. (A) Construction of the PPI network of 38 EP-DEGs via the STRING database. (B) A total of eight candidate genes were identified from EP-DEGs according to the score sorted by the MCODE method using Cytoscape. (C) Top 10 genes were obtained according to the score calculated by the MCC method. (D) Top 10 genes were selected according to the score calculated by the Degree method. (E) Venn diagram displaying four key genes such as LUM, TGFBI, COL1A2, and POSTN acquired by the intersection of the three methods (MCC, Degree, and MCODE). The other genes obtained from the intersection between MCC and Degree methods were C1QB and C1QA. The other genes obtained from the intersection between MCC and MCODE methods were COL3A1, COL6A3, COL4A2, and COL4A1.