Table III.
Association between some phenotypic traits and variants.
| Q705K | c.393G>A | c.278-2A>G | |||||||
|---|---|---|---|---|---|---|---|---|---|
|
|
|
|
|||||||
| Phenotype | CC | CA | P-value | GG | GA | P-value | AA | AG | P-value |
| Family history, n (%) | 0.930a | 0.043a | 0.426a | ||||||
| With | 45 (77.6) | 13 (22.4) | 45 (77.6) | 13 (22.4) | 50 (86.2) | 8 (13.8) | |||
| Without | 50 (23.1) | 15 (76.9) | 59 (90.8) | 6 (9.2) | 59 (90.8) | 6 (9.2) | |||
| Age of onset, n (%) | 0.460a | 0.351a | 0.003a | ||||||
| Early-onset | 27 (73) | 10 (27) | 33 (89.2) | 4 (10.8) | 28 (75.7) | 9 (24.3) | |||
| Late-onset | 68 (79.1) | 18 (20.9) | 71 (82.6) | 15 (17.4) | 81 (94.2) | 5 (5.8) | |||
| Lithium treatment, n (%) | 0.149a | 0.094a | 0.341a | ||||||
| With | 48 (82.8) | 10 (17.2) | 45 (77.6) | 13 (22.4) | 53 (91.4) | 5 (8.6) | |||
| Without | 40 (71.4) | 16 (28.6) | 50 (89.3) | 6 (10.7) | 48 (85.7) | 8 (14.3) | |||
| Scales (mean ± SD) | |||||||||
| HAM-D | 3.71±4.47 | 4.81±6.73 | 0.324b | 3.93±5.19 | 4.16±4.49 | 0.858b | 4.12±5.32 | 2.86±2.18 | 0.385b |
| YMRS | 2.11±5.99 | 1.15±2.14 | 0.416b | 2.06±5.82 | 1±1.2 | 0.432b | 1.98±5.69 | 1.21±1.48 | 0.618b |
| GAF | 81.31±11.3 | 78.63±11.09 | 0.281b | 80.66±11.19 | 80.84±12.09 | 0.950b | 80.52±11.47 | 81.93±10.14 | 0.664b |
| FAST | 6.63±7.18 | 7.67±6.59 | 0.505b | 7.13±7.52 | 5.53±3.36 | 0.364b | 7.01±7.37 | 5.86±3.71 | 0.567b |
Data are presented as the number (%) and mean ± SD. N, number of individuals.
a
The Chi-squared test was used for statistical analysis.
b
The Independent samples t-test was used for statistical analysis. P<0.05 was considered to indicate a statistically significant difference. SSD, standard deviation; HAM-D, Hamilton depression rating scale; YMRS, Young mania rating scale; GAF, global assessment of functioning; FAST, functioning assessment Short Test.