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. 2022 Jul 28;26(3):290. doi: 10.3892/mmr.2022.12806

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Copyright: © Chen et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — ox-LDL increases the expression of circ_0005699 in HUVECs. Expression levels of circ_0005699 were increased by ox-LDL in a (A) dose-dependent and (B) time-dependent manner. **P<0.01 vs. 0 µg/ml ox-LDL or 0 h ox-LDL. (C) ELISA indicated the effect of ox-LDL on the concentration of inflammatory factors in HUVECs. (D) Effect of ox-LDL on the apoptotic rate of HUVECs, as determined by Annexin V/PI double staining and flow cytometry. (E) circ_0005699 was highly expressed in ApoE-knockout mice. (F) Serum levels of circulating inflammatory cytokines in control and ApoE-knockout mice. **P<0.01 vs. control. ApoE, apolipoprotein E; HUVEC, human umbilical vein endothelial cell; ox-LDL, oxidized low-density lipoprotein.