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. 2022 Jan 29;12(8):3313–3325. doi: 10.1016/j.apsb.2022.01.015

Figure 2.

Figure 2

NAT10 is a driver gene for MM malignancy in vitro and in vivo. (A, B) Confirmation of NAT10 expression in NAT10-OE and siNAT10 MM cells by RT-qPCR (n = 3) (A) and Western blotting (B). (C) MTT assay showed that increased NAT10 enhanced cellular proliferation and siNAT10 impeded cell growth in MM cells (n = 6). (D) Photographic images of harvested xenograft tumors (n = 6). (E) Mean tumor volume and weight from WT and NAT10-OE xenograft mice on Day 32. (F) IHC staining showed that NAT10 protein level was elevated in NAT10-OE xenograft tumor tissues and NAT10 expression was positively correlated with Ki67 expression in xenograft tumor tissues. All data are displayed as mean ± SD; ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.