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. 2022 Jan 29;12(8):3313–3325. doi: 10.1016/j.apsb.2022.01.015

Figure 4.

Figure 4

NAT10 acetylates mRNA to regulate progression of MM cells. (A) Dot blot assay showed that increased NAT10 led to higher mRNA acetylation level and conversed result was observed in siNAT10 MM cells. (B) Schematic of acRIP-seq. (C) Typical CXX motif of ac4C peaks. (D) ac4C peaks mainly occurred within CDS and 3′UTR in MM cells. (E) Volcano plot described genes with upregulated (red) and downregulated (blue) mRNA acetylation levels upon NAT10 overexpression. (F) GO analysis of acRIP-seq. All data are displayed as mean ± SD; ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.