Figure 7.

Remodelin impedes MM cell growth in vitro and prolongs the survival of 5TMM3VT mice in vivo. (A) Inhibition ratio of remodelin in MM cells (n = 4). (B) Remodelin induced cell cycle arrest (n = 3). (C) Flow cytometry analysis indicated that remodelin induced MM cell apoptosis (n = 3). (D) Western blotting analysis showed that remodelin promoted apoptotic protein expression and reduced CDK4 and CDK6 expression. (E) Photographic images of harvested xenograft tumors (n = 5). (F) Representative micrographs of TUNEL assay in tissues from xenograft mice treated with remodelin. (G) Remodelin extended the survival period of myeloma mice in vivo (n = 8). All data are displayed as mean ± SD; ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001.