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. 2022 Feb 14;12(8):3410–3426. doi: 10.1016/j.apsb.2022.02.007

Figure 5.

Figure 5

The nano-drug siIRAK4/Er@GEM-SS-PC-M reprograms fibrotic tumor environment. (A) The expression of hENT1 and the phosphorylation of EGFR were determined by Western blot. (B) The expression of IRKA4 and the phosphorylation of p-65 were determined by Western blot. (C) The secretion of IL-1β was determined by ELISA. (D) Representative images of Sirius Red positive area in tumors. Scale bar = 50 μm. (E) Representative images of α-SMA positive area in tumors. Scale bar = 50 μm. (F) Representative images of Ki67 positive area in tumors. Scale bar = 50 μm. (G) Representative images of TUNNEL positive area in tumors. Scale bar = 50 μm. (H) Quantitative analysis of Sirius Red, α-SMA, Ki67, TUNNEL positive area in tumors (mean ± SD, n = 4).