Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 14;12(8):3410–3426. doi: 10.1016/j.apsb.2022.02.007

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting.

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Scheme 1 — Construction of cancer cell-macrophage hybrid membrane-coated drug-delivery nanosystem for pancreatic cancer treatment. (A) Schematic illustration for the preparation of siIRAK4/Er@GEM-SS-PC-M: gemcitabine (GEM) is conjugated with PC by a GSH-responsive linker to form GEM prodrug, followed by encapsulating the Erlotinib (Er) via host‒guest molecular interaction and loading with the siRNA to form cell membrane-coated nano-drug (siIRAK4/Er@GEM-SS-PC-M). (B) Schematic illustration of targeted nanoparticles to deliver to GEM, Er and siIRAK4 against pancreatic tumors including orthotopic pancreatic tumor and patient-derived tumor (PDX).