TABLE 2.
The associations between the nutritional status and the risk of LP in patients with osteosarcoma during chemotherapy (n = 245).
| Characteristic | Patients at risk, (N) | Events, (n) | Model A* | Model B† | Model C‡ | |||
|
|
|
|
||||||
| Univariate OR (95% CI) | P-value | Multivariable OR (95% CI) | P-value | Multivariable OR (95% CI)) | P-value | |||
| Adolescent | ||||||||
| Nutrient status Normal |
67 |
23 |
1 (Reference) |
|
1 (Reference) |
|
1 (Reference) |
|
| Mild | 46 | 29 | 3.26 (1.51-7.27) | 0.003 | 3.39 (1.52-7.81) | 0.003 | 6.85 (2.16-25.43) | 0.002 |
| Severe | 30 | 27 | 17.22 (5.37-77.63) | <0.001 | 17.33 (5.31-79.27) | <0.001 | 35.03 (6.98-238.46) | <0.001 |
| Adult | ||||||||
| Nutrient status Normal |
58 |
15 |
1 (Reference) |
|
1 (Reference) |
|
1 (Reference) |
|
| Mild | 19 | 11 | 3.94 (1.35-12.06) | 0.013 | 5.24 (1.62-18.56) | 0.007 | 6.06 (1.43-30.16) | 0.019 |
| Severe | 25 | 22 | 21.02 (6.21-98.27) | <0.001 | 26.55 (7.30-136.06) | <0.001 | 38.09 (7.23-285.78) | <0.001 |
*Model A: crude analysis; †Model B: adjusted for sex and age; ‡Model C: adjusted for sex, age, BMI, PS, location, pathology, MSTS staging, Ki67, CRP, HGB, PLT, WBC before, and ALB.