Table 6.
Representative clinical trials of IN delivering stem cells or EVs for the treatment of CNS diseases.
| Condition | NCT numbers | Phase | Intervention | Status | Ref. |
|---|---|---|---|---|---|
| Ischemic stroke | NCT05008588 | Phase I/II | IN delivery of MSC's condition medium | Not yet recruiting | N/A |
| Perinatal arterial ischemic stroke | NCT03356821 | Phase I/II | IN administration of MSCs at confirmation of the stroke and within the first week of onset | Completed | N/A |
| Alzheimer's disease | NCT03724136 | N/A | IN administration of MSCs | Recruiting | N/A |
| Parkinson's disease | NCT04146519 | Phase II/III | Tandem (IN + intravenous) injections of MSCs | Recruiting | 163 |
| Multiple CNS diseases | NCT03899298 | Phase I | IN delivery of amniotic and umbilical cord tissue | Recruiting | N/A |
Resource the clinical trial is from ClinicalTrials.gov.
MSCs, mesenchymal stem cells; CNS, central nerve system; IN, intranasal; N/A, not applicable.