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. 2022 Jul 28;13:960918. doi: 10.3389/fimmu.2022.960918

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Copyright © 2022 Roels, Van Hulle, Lavaert, Kuchmiy, Strubbe, Putteman, Vandekerckhove, Leclercq, Van Nieuwerburgh, Boehme and Taghon

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Expression of ID protein encoding genes exhibits different patterns in the pre- and postnatal thymocytes. (A) Pseudo-bulk expression of E and ID protein encoding genes in thymocytes based on prenatal and pediatric single cell data sets. The prenatal data was divided into embryonic (≤10 wpc) and fetal (>10 wpc) samples. Note that only very few SP, early/late CD4⁺ and CD8⁺ SP thymocytes were detected in embryonic samples (see Figure S7C). (B) Average E:ID score per cell type in embryonic, fetal, and pediatric thymocytes.