Table 2.

General recommendations for genetic testing in the context of kidney transplantation

General recommendations
•Thorough assessment of renal phenotype in potential kidney transplant recipients is an important first step toward genetic diagnosis
•Thorough family medical history
•Affected transplant recipient to undergo genetic testing first
•Selection of known disease-associated genes that match phenotype
•Involvement of renal genetics multidisciplinary team for test guidance, pretest counseling, test interpretation, and/or delivery of results, and cascade screening of relatives
•If pathogenic or likely pathogenic variant identified, can test potential live related donors for the same variant after genetic counseling