Table 3.

Effect estimates in non-Hispanic Blacks for clinical phenotypes that were significantly associated with the rs4293393 (A/G) UMOD variant in non-Hispanic White patients in the Million Veteran Program

Clinical phenotypes	Million Veteran Program
	PheWAS code description	Cases	Controls	OR (95% CI) per copy of the A allele	P value
CKD	CKD	19,540	90,000	1.02 (0.99–1.05)	1.14 × 10−01
	CKD, stages I–II	4583	106,035	1.03 (0.98–1.09)	2.61 × 10−01
	CKD, stage III	11,929	99,163	1.03 (0.99–1.07)	9.57 × 10−02
	CKD, stage IV	3953	109,453	1.06 (1.00–1.12)	4.58 × 10−02
Diabetic kidney disease	Type 2 diabetes with renal manifestations	8393	102,371	1.01 (0.97–1.05)	7.76 × 10−01
Proteinuria	Proteinuria	4357	106,600	1.02 (0.96–1.07)	5.38 × 10−01
End-stage kidney disease and related disorders	End-stage kidney disease	3873	109,875	1.04 (0.98–1.10)	1.91 × 10−01
	Renal failure, NOS	3205	108,717	1.02 (0.96–1.08)	5.82 × 10−01
	Secondary hyperparathyroidism of renal origin	2860	110,654	1.03 (0.96–1.10)	3.92 × 10−01
	Anemia of CKD	4347	108,345	1.04 (0.98–1.04)	2.00 × 10−01
	Disorders resulting from impaired renal function	3478	109,570	1.02 (0.97–1.09)	3.57 × 10−01
Acute kidney injury	Acute renal failure	13,954	92,382	1.01 (0.98–1.05)	3.90 × 10−01
Electrolyte imbalance	Electrolyte imbalance	17,004	86,178	1.01 (0.98–1.04)	4.66 × 10−01
Hyperkalemia	Hyperpotassemia	4517	105,759	1.05 (1.00–1.11)	4.94 × 10−02
Hypertension and complications	Hypertension	87,895	21,857	0.99 (0.96–1.02)	6.96 × 10−01
	Essential hypertension	87,503	22,156	0.99 (0.97–1.02)	7.26 × 10−01
	Hypertensive CKD	12,633	96,524	1.03 (1.00–1.06)	7.60 × 10−02
	Hypertensive heart or renal disease	19,685	86,457	1.03 (1.00–1.06)	3.68 × 10−02
Gout	Gout	13,193	97,948	1.02 (0.98–1.05)	3.62 × 10−01
Anemia	Anemia of chronic disease	6641	103,775	1.03 (0.98–1.05)	3.62 × 10−01
	Other anemias	29,742	73,176	1.01 (0.98–1.03)	5.57 × 10−01
UTIs	UTI	13,886	88,161	1.02 (0.98–1.05)	2.45 × 10−01
Urinary calculi	Urinary calculus	5323	105,846	0.95 (0.90–0.99)	2.49 × 10−02
	Calculus of the kidney	4435	107,159	0.95 (0.91–1.01)	7.83 × 10−01
	Calculus of the ureter	1201	112,536	0.91 (0.83–1.01)	6.87 × 10−01
	Calculus of the lower urinary tract	394	113,757	0.91 (0.77–1.07)	2.59 × 10−01
	Hydronephrosis	1354	111,996	0.94 (0.86–1.03)	2.18 × 10−01
Hematuria	Hematuria	11,005	95,973	1.02 (0.98–1.05)	3.52 × 10−01
	Gross hematuria	3922	107,820	1.04 (0.98–1.10)	2.08 × 10−01

CKD, chronic kidney disease; NOS, not otherwise specified; OR, odds ratio; PheWAS, phenome-wide association study.