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. 2022 Jul 28;10:954735. doi: 10.3389/fped.2022.954735

TABLE 3.

Targeting TLR4 by drugs in NEC.

Name Species Outcome Year References
Pregnane X receptor Mouse Anti-inflammation via TLR4. 2018 (72)
The secondary bile acid lithocholic acid (LCA) Mouse LCA activated PXR, anti-inflammation via TLR4. 2018 (72)
High mobility group box-1 inhibitor glycyrrhizin (GL) Rat Anti-inflammation via TLR4/NF-kB/NLRP3. 2010 (78)
Interleukin-1 (IL-1) receptor-associated kinase (IRAK) inhibitors Rat Anti-inflammation via TLR4. 2018 (73)