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WS-716 binds directly to P-glycoprotein (P-gp). (A) The interaction of WS-716 and P-gp was assessed through cellular thermal shift assay. (B) The ribbon diagram of P-gp with the binding location of WS-716 at the internal cavity. (C) The 2D bonding interaction of WS-716 within P-gp (PDB code: 6FN1). (D) The 3D ligand–receptor interaction diagram of WS-716 and P-gp.
