Table 1.
Effect of WS-716 on reversing paclitaxel (PTX) resistance against SW620/Ad300 cells.
| Treatment | IC50 of PTX (nmol/L)a [RF]b |
|
|---|---|---|
| SW620 | SW620/Ad300 | |
| PTX | 7.69 ± 2.78 [1.00] | 4233.18 ± 499.10 [1.00] |
| PTX + WS-716 (10 μmol/L) | 6.19 ± 1.52 [1.24] | 89.58 ± 5.31 [47.26] |
| PTX + WS-716 (20 μmol/L) | 4.49 ± 0.35 [1.71] | 46.65 ± 6.98 [90.74] |
| PTX + VPM (4 μmol/L) | 7.11 ± 2.88 [1.08] | 303.53 ± 47.93 [13.95] |
a
Data are presented as the mean ± SD (n = 3).
b
The RF was calculated by dividing the IC50 of PTX in the absence of reversal agent with the IC50 of PTX in the presence of reversal agent.