TABLE 1.
Comparisons of lymphocyte subset absolute counts among the different groups divided by clinical parameters in 217 simple PTB patients
| Groups | Cases | Mean ± SD of absolute lymphocyte subset counts (cells/μl) | P‐value | |||||
|---|---|---|---|---|---|---|---|---|
| T subset | CD4+ subset | CD8+ subset | NK subset | NKT subset | B subset | |||
| Age | ||||||||
| ≤25 | 47 | 1247 ± 425.1 a1 (73.18 ± 6.69) | 675.5 ± 263.5 a2 (39.49 ± 6.67) | 482.4 ± 181.5a3,b3 (28.52 ± 6.14) | 181.4 ± 110.8 (10.52 ± 5.43) | 64.2 ± 49.5 (3.89 ± 2.77) | 254.5 ± 162.5 a4 (14.26 ± 6.18) |
a1, 0.006; b1, 0.000; c1, 0.012 a2, 0.026; b2, 0.000; c2, 0.029; d,0.044 a3, 0.048; b3, 0.015; c3, 0.005 a4, 0.000; b4, 0.000; c4, 0.005 |
| 26–44 | 61 | 1378 ± 733.2 b1,c1 (71.19 ± 9.09) | 803.3 ± 460.4 b2,c2 (41.81 ± 9.65) | 502.0 ± 313.1 b3c3 (25.77 ± 6.73) | 263.4 ± 242.8 (13.79 ± 8.97) | 93.0 ± 97.0 (5.18 ± 6.41) | 250.8 ± 148.5 b4 (13.15 ± 6.03) | |
| 45–59 | 53 | 1110 ± 553.3 c1 (72.16 ± 9.41) | 656.1 ± 376.1 c2,d (41.95 ± 9.27) | 409.3 ± 227.0 a3 (27.02 ± 10.22) | 190.5 ± 122.1 (12.96 ± 6.66) | 88.4 ± 84.6 (5.67 ± 4.37) | 205.5 ± 151.2 c4 (12.91 ± 6.36) | |
| ≥60 | 56 | 935.5 ± 450.2a1,b1 (70.55 ± 11.10) | 517.9 ± 263.1a2,b2,d (39.45 ± 9.42) | 388.9 ± 236.5c3 (28.76 ± 10.83) | 219.6 ± 164.4 (16.80 ± 10.57) | 74.1 ± 70.3 (5.47 ± 4.63) | 130.1 ± 89.4 a4,b4,c4 (10.14 ± 5.95) | |
| Gender | ||||||||
| Male | 136 | 1211.4 ± 599.1 (71.91 ± 9.69) | 690.3 ± 377.5 (40.75 ± 8.99) | 459.6 ± 261.0 (27.56 ± 8.83) | 223.9 ± 150.4 (14.13 ± 8.88) | 90.9 ± 89.5 a (5.51 ± 5.36) | 209.4 ± 152.4 (11.95 ± 6.08) | a, 0.0257 |
| Female | 81 | 1078.1 ± 553.4 (71.21 ± 9.26) | 615.3 ± 356.4 (40.75 ± 8.99) | 411.4 ± 228.5 (27.34 ± 9.97) | 207.2 ± 206.7 (13.43 ± 8.28) | 66.1 ± 56.2 a (4.83 ± 5.23) | 206.7 ± 142.9 (13.40 ± 6.71) | |
| Aetiological examination | ||||||||
| Negative | 71 | 1255 ± 78.09 (71.81 ± 9.84) | 704.5 ± 46.0 (39.11 ± 8.86) | 479.3 ± 34.1 (28.29 ± 7.36) | 208.5 ± 16.7 (13.63 ± 9.36) | 78.42 ± 8.7 (5.06 ± 3.95) | 219.2 ± 17.9 (12.56 ± 5.89) | |
| Positive | 125 | 1110 ± 47.41 (71.69 ± 8.53) | 636.5 ± 31.1 (41.47 ± 8.48) | 422.6 ± 20.8 (27.31 ± 10.20) | 214.7 ± 13.5 (13.79 ± 7.51) | 85.03 ± 7.7 (5.93 ± 6.73) | 205.6 ± 13.3 (12.71 ± 6.73) | |
| Chest radiography | ||||||||
| 1 lobe | 47 | 1501.0 ± 663.2 a1,b1 (72.76 ± 6.72) | 845.7 ± 490.9 a2,b2 (39.50 ± 8.53) | 571.9 ± 224.3 a3,b3 (29.00 ± 8.03) | 241.4 ± 126.9 (12.36 ± 6.20) | 95.9 ± 91.0 (4.90 ± 4.34) | 275.2 ± 170.6 a4 (12.83 ± 4.68) |
a1, 0.000; b1, 0.002 a2,0.000; b2, 0.016 a3, 0.000; b3, 0.001 a4,0.000; b4, 0.038 |
| 2 ~ 3 lobes | 59 | 1165.6 ± 495.5 b1 (70.29 ± 8.47) | 675.6 ± 327.5 b2 (40.74 ± 8.36) | 416.1 ± 174.5 b3 (25.63 ± 6.84) | 233.8 ± 228.7 (14.17 ± 9.21) | 75.2 ± 66.0 (4.42 ± 3.44) | 222.6 ± 134.4 b4 (13.32 ± 5.12) | |
| 4 ~ 5 lobes | 111 | 1032.5 ± 540.2 a1 (71.98 ± 10.53) | 584.9 ± 300.0 a2 (41.25 ± 9.43) | 408.4 ± 280.0 a3 (27.75 ± 9.85) | 196.8 ± 157.5 (13.94 ± 8.98) | 77.3 ± 80.0 (5.53 ± 5.62) | 174.5 ± 134.3a4,b4 (12.03 ± 7.32) | |
| Cavities | ||||||||
| 0 | 73 | 1310.5 ± 652.2 a1 (74.50 ± 7.80) | 719.9 ± 406.0 (40.32 ± 9.50) | 520.9 ± 300.8 a2,b (30.04 ± 10.01) | 199.2 ± 215.0 (10.77 ± 6.66) | 229.1 ± 162.2 (4.86 ± 4.48) | 1310.5 ± 652.2 (12.73 ± 6.66) | a1, 0.014; a2, 0.001; b, 0.01 |
| 1–2 | 76 | 1138.5 ± 445.7 (69.89 ± 9.46) | 651.6 ± 282.1 (39.97 ± 8.92) | 416.5 ± 181.0 b (26.05 ± 7.56) | 243.3 ± 144.6 (15.50 ± 9.09) | 200.1 ± 111.4 (4.36 ± 3.00) | 1138.5 ± 445.7 (12.11 ± 4.89) | |
| 3–4 | 24 | 1089.9 ± 550.3 (70.83 ± 9.94) | 606.5 ± 322.7 (40.57 ± 8.29) | 457.9 ± 274.3 (28.56 ± 10.04) | 202.7 ± 159.4 (13.30 ± 7.01) | 231.5 ± 152.1 (5.35 ± 4.16) | 1089.9 ± 550.3 (14.37 ± 6.61) | |
| ≥5 | 44 | 1035.6 ± 662.4 a1 (70.61 ± 10.07) | 633.82 ± 454.0 (42.84 ± 8.33) | 365.8 ± 226.0 a2 (24.95 ± 6.67) | 206.5 ± 154.5 (15.46 ± 9.81) | 180.8 ± 174.0 (6.59 ± 7.48) | 1035.6 ± 662.4 (12.05 ± 7.43) | |
Notes: The contents in parentheses indicate the percentage (%) of the absolute count of the corresponding lymphocyte subsets. In the age group, a1 represents the difference of the counts of T subset between the patients (≥60) and the patients (≤25), b1 represents the difference of the counts of T subset between the patients (≥60) and the patients (26–44), and c1 represents the difference of the counts of T subset between the patients (45–59) and the patients (26–44). a2 represents the difference of the counts of CD4+ subset between the patients (≥60) and the patients (≤25), b2 represents the difference of the counts of CD4+ subset between the patients (≥60) and the patients (26–44), c2 represents the difference of the counts of CD4 subset between the patients (45–59) and the patients (26–44), and d2 represents the difference of the counts of CD4 subset between the patients (≥60) and the patients (45–59). a3 represents the difference of the counts of CD8 subset between the patients (45–59) and the patients (≤25), b3 represents the difference of the counts of CD8 subset between the patients (≤25) and the patients (26–44), and c3 represents the difference of the counts of CD8 subset between the patients (45–59) and the patients (≥60). a4 represents the difference of the counts of B subset between the patients (≥60) and the patients (≤25), b4 represents the difference of the counts of B subset between the patients (≥60) and the patients (26–44), and c4 represents the difference of the counts of B subset between the patients (45–59) and the patients (≥60). The absolute counts of T, CD4+, CD8+, NK, NKT and B lymphocytes peaked at age 26–44 and then decreased gradually with an increase in age. This trend was especially notable for T, CD4+, CD8+ and B lymphocytes; the absolute counts in PTB patients aged over 60 were significantly lower (P < 0.05) than those of patients aged 26–44. In the gender group, a represents the difference of the counts of NKT subset between the patients (male) and the patients (female). In the gender group, there was significant difference of the counts of NKT subset between the patients (male) and the patients (female). In the pathogenic examination group, there was no significant difference of the absolute counts of lymphocyte subsets between the two groups. In the chest radiography group, a1 represents the difference of the counts of T subset between the patients (one lobe) and the patients (four to five lobes), and b1 represents the difference of the counts of T subset between the patients (one lobe) and the patients (two to three lobes). a2 represents the difference of the counts of CD4+ subset between the patients (one lobe) and the patients (four to five lobes), and b2 represents the difference of the counts of CD4+ subset between the patients (one lobe) and the patients (two to three lobes). a3 represents the difference of the counts of CD8+ subset between the patients (one lobe) and the patients (four to five lobes), b3 represents the difference of the counts of CD8+ subset between the patients (one lobe) and the patients (two to three lobes). a4 represents the difference of the counts of B subset between the patients (one lobe) and the patients (four to five lobes), and b4 represents the difference of the counts of B subset between the patients (two to three lobes) and the patients (four to five lobes). The absolute counts of T, CD4+, and CD8+ T lymphocytes were higher in the one lobe group than in the other two groups, and the levels of B lymphocytes in the one lobe and two to three lobe groups were significantly higher than in the four to five lobe group; the absolute counts of NK and NKT cells also showed a decreasing trend with the severity of the lesion, but there was no significant difference among the groups. In the cavities group, a1 represents the difference of the counts of T subset between the patients (zero cavity) and the patients (≥5 cavities). a2 represents the difference of the counts of CD8 subset between the patients (zero cavity) and the patients (≥5 cavities), b represents the difference of the counts of CD8 subset between the patients (0) and the patients (one to two cavities). The absolute counts of T, CD4+ and CD8+ lymphocytes were highest in the no cavity group and showed a downward trend as the number of cavities increased. The absolute count of T lymphocytes in the no cavity group was significantly higher than in the five or more cavities group, and the absolute count of CD8+ lymphocytes in the no cavity group was significantly higher than in the one to two cavities group and the five or more cavities group. There was no apparent change among the other four lymphocyte subsets.