Table I.
Sensitivities and specificities of different serological tests for the diagnosis of epidermolysis bullosa acquisita (EBA)
| Patients | Indirect IF on SSS (blister floor) n (%) | NC1 BIOCHP® n (%) | NC1 ELISA n (%) | NC1/NC2 ELISA n (%) | FL Col7 ELISA n (%) | Dermal extract IB (Col7) n (%) | NC1 IB n (%) |
|---|---|---|---|---|---|---|---|
| EBA (n = 101) | 97 (96.0) | 90 (89.1) | 83 (82.2) | 89 (88.1) | 81 (80.2) | 88 (87.1) | 94 (93.1) |
| BP (n = 99) | 5 (5.1) | 0 (0) | 1 (1) | 4 (4) | 6 (6.1) | 0 (0) | 0 (0) |
| PV (n = 40) | 0 (0) | 0 (0) | 0 (0) | 1 (2.5) | 2 (5.0) | 0 (0) | 0 (0) |
| Anti-p200 pemphigoid (n = 65) | 65 (100) | 0 (0) | 2 (3.1) | 8 (12.3) | 3 (4.6) | 0 (0) | 0 (0) |
| Anti-laminin332 MMP (n = 6) | 6 (100) | 0 (0) | 0 (0) | 1 (16.7) | 2 (33.3) | 0 (0) | 0 (0) |
| Specificity | 97.6% | 100% | 98.6% | 93.3% | 93.8% | 100% | 100% |
| Sensitivity + Specificity | 193.6% | 189.1% | 180.8% | 181.4% | 174.4% | 187.1% | 193.1% |
BP: bullous pemphigoid; Col7: type VII collagen; NC: non-collagenous domain; FL: full-length; IF: immunofluorescence; IB: immunoblot; MMP: mucous membrane pemphigoid; PV: pemphigus vulgaris; SSS: salt-split skin.