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. 2022 Aug 6;16:2601–2616. doi: 10.2147/DDDT.S344247

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© 2022 Hassan et al.

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Magnitude of colonic inflammatory reactions following acute diclofenac toxicity (group II). (A–D): Photomicrographs of sections of the colon of rats in group II (acute diclofenac toxicity group) showing complete destruction of crypts architecture (C) and patchy loss of the crypts (arrow) in some areas. Loss of surface epithelium is noted (stars). Absence of goblet cells and submucosal exudate (curved arrow) are also seen. The lumen of some crypts contains cellular debris (double headed arrow). There is heavy infiltration of the lamina propria and submucosa with inflammatory cells mainly lymphocytes (I) and eosinophils in the lamina propria (bifid arrow). Notice areas of haemorrhage in the mucosa (H) and dilated congested blood vessel (BV) in the submucosa. (H&E, x400).