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. Author manuscript; available in PMC: 2022 Aug 11.
Published in final edited form as: J Am Soc Mass Spectrom. 2018 Jul 17;29(10):2012–2022. doi: 10.1007/s13361-018-2013-z

Table 1. Gene Ontology Pathway Analysis.

The top five canonical pathways enriched from the differentially regulated proteins of each treatment condition determined using IPA

Full nutrients with IR No glucose No glucose with IR
Canonical pathway p value Canonical pathway p value Canonical pathway p value
Granzyme A signaling 1.50E–03 Sirtuin Signaling Pathway 8.81E-12 IGF-1 Signaling 1.39E-06
Pyrimidine deoxyribonucleotides de novo biosynthesis I 1.99E–03 Mitochondrial Dysfunction 4.58E-08 p70S6K Signaling 4.11E-06
Oxidative phosphorylation 3.84E–03 Oxidative Phosphorylation 3.52E-05 ERK5 signaling 6.36E-06
Sirtuin signaling pathway 4.04E-03 Granzyme A Signaling 1.84E-04 Myc Mediated Apoptosis Signaling 8.04E-06
p53 Signaling 9.99E–03 Acute phase response signaling 2.76E-03 ERL/MAPK Signaling 3.08E-05