Table 4.

Hematological values in transgenic mice and control group. One, two or three characters represent p ≤ 0.05, p ≤ 0.01, or p ≤ 0.001, respectively.

Parameter	Age [weeks]	Genotype
		C57BL6J	Apoe−/−	Apoe+/−	Hbb+/−	Apoe+/−/Hbb+/−
RBC [106/μl]	16	6.28 ± 0.72	7.35 ± 0.28	7.15 ± 0.42	3.06 ± 0.64**	7.48 ± 0.41&&
	24	6.69 ± 0.37	8.03 ± 0.51	7.76 ± 0.37	4.98 ± 0.96*#	6.56 ± 0.46
HGB [g/dl]	16	13.10 ± 1.47	15.41 ± 0.31	14.35 ± 0.89	5.51 ± 1.52***	12.92 ± 0.69&&
	24	12.11 ± 0.63	15.20 ± 1.11	14.70 ± 1.40	8.45 ± 1.14*#	10.75 ± 0.52
HCT [%]	16	30.95 ± 2.61	40.54 ± 0.51*	35.22 ± 1.98	12.94 ± 3.21**	26.17 ± 2.31&
	24	29.96 ± 1.39	38.04 ± 1.98	33.99 ± 3.45	18.32 ± 3.35*	22.27 ± 0.87
MCV [fl]	16	49.67 ± 1.45	50.99 ± 1.02	49.25 ± 0.63	36.02 ± 0.99**	34.99 ± 1.03**
	24	48.03 ± 0.79	47.51 ± 2.48	43.20 ± 2.81	36.75 ± 3.09*	34.25 ± 1.11**
MCH [pg]	16	20.87 ± 0.61	19.25 ± 0.35	20.07 ± 0.49	17.84 ± 1.25	17.50 ± 0.28*
	24	19.37 ± 0.23	18.51 ± 0.48	18.74 ± 1.08	16.95 ± 0.92	16.43 ± 0.39*
MCHC [g/dl]	16	42.08 ± 1.41	39.30 ± 0.51	40.75 ± 1.44	49.15 ± 3.34	49.34 ± 1.65*
	24	40.27 ± 0.33	39.23 ± 0.47	43.44 ± 0.79	46.37 ± 1.69	48.13 ± 0.64*
RDW [fl]	16	31.50 ± 0.68	36.15 ± 2.14	33.17 ± 0.98	47.31 ± 0.42***	48.85 ± 1.94***
	24	30.64 ± 0.39	35.64 ± 2.66	34.06 ± 2.10	41.05 ± 3.85*#	44.57 ± 2.04**
RDW [%]	16	16.29 ± 1.02	19.25 ± 0.23	17.22 ± 0.73	33.83 ± 0.84***	35.86 ± 0.43***
	24	16.56 ± 0.44	18.52 ± 0.48	20.64 ± 2.32	30.07 ± 2.75**#	33.52 ± 1.18***

*In comparison to C57BL6J genotype.

^&In comparison to mice with Hbb^+/− genotype.

^#Mice in 16-week vs. mice in 24-week.