Table 3.
Summarized the clinical effect of probiotics in the treatment of BV.
| Probiotics | Methods | Results | Ref. |
|---|---|---|---|
| Lactobacillus acidophilus GLA-14 and Lactobacillus rhamnosus HN001 | Patients received metronidazole (500 mg, bid) for 7 days and were randomly assigned to concurrently receive probiotics plus lactoferrin or placebo (n=48). | Probiotic mixture combined with lactoferrin improved symptoms (vaginal discharge and itching), Nugent scores, and recurrence rates. | Russo et al., 2019 |
| Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 | Patients received oral metronidazole for 7 days, and probiotics and placebo for 30 days (n=125). | Combined use of probiotics and antibiotics improves BV cure rates. | Anukam et al., 2006 |
| Lactobacillus crispatus LMG S-29995, Lactobacillus brevis, and Lactobacillus acidophilus | After completing metronidazole treatment, patients received probiotics and placebo, respectively (n=166). | Oral probiotics reduce the rate of BV recurrence and prolong the time to disease recurrence. | Reznichenko et al., 2020 |
| Lactobacillus rhamnosus BMX 54 | After completing metronidazole treatment, patients received placebo and vaginal tablets containing probiotics, respectively (n=250). | Patients treated with probiotics had reduced BV recurrence rate and vaginal pH. | Recine et al., 2016 |
| Lactobacillus crispatus LbV 88, Lactobacillus gasseri LbV 150N, Lactobacillus jensenii LbV 116 and Lactobacillus rhamnosus LbV96 | After completing metronidazole treatment, patients received placebo and yogurt with probiotics, respectively (n=36). | Yogurt with probiotics increases BV recovery rates and improves vaginal microbes. | Laue et al., 2018 |
| L. brevis CD2, L. salivarius subsp. salicinius, L. plantarum | Patients were randomized to receive probiotic vaginal tablets and vaginal pH tablets (n=64). | Probiotics improve BV cure rates and reduce vaginal cytokines IL-1β and IL-6. | Hemalatha et al., 2012 |
| Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 | Patients were treated with probiotics for 6 months and metronidazole for 10 days (n=65). | Supplementation with probiotics did not improve BV cure rates, but improved vaginal flora composition. | Hummelen et al., 2010 |
| L. brevis (CD2), L. salivarius subsp.salicinius (FV2), and L. plantarum (FV9) | Patients received probiotic-containing vaginal tablets or placebo for 7 days (n=39). | Supplementation with probiotics can increase the cure rate of BV and improve the vaginal environment. | Mastromarino et al., 2009 |