TABLE 1.

Histones and Chromatin modifiers which are altered during ageing.

Name	Type	Expression pattern	Model organism	References
Histones
H3, H4,  H2A, H2B	Canonical histones	Loss	Yeast	Feser and Tyler, (2011)
H3	Canonical histone	Loss	C.elegans	Faget et al. (2019)
H3, H2A.1, H4	Canonical histone	Loss	Human fibroblasts	Kennedy et al. (1995)
mH2A, H2A.Z, H2A.J	Histone variant	Accumulation	Human, mouse	(Narita et al., 2003; Chandra et al., 2012; Di Giorgio et al., 2020)
H3.3	Histone variant	Accumulation	Human, mouse	(Zhang et al., 2007; Sen et al., 2019)
H1.0	Histone variant	Accumulation	Human fibroblasts	Eriksson et al. (2003)
Chromatin remodelers
SWI/SNF	ATP chromatin remodeler	Loss results in shorter lifespan	C.elegans	Malaquin et al. (2013)
ISW1/ITCH	Chromatin remodeler	Loss results in extended lifespan	Yeast	Kaur et al. (2019)
Histone modifying enzymes
SET-1	Histone lysine methyltransferase (ASH-2 complex subunit)	Loss	C.elegans	Oberdoerffer and Sinclair, (2007)
EZH2	Histone methyltransferase	Loss	Mouse, human fibroblasts	Zhang et al. (2020)
SUV39H1	Histone methyltransferase	Loss	Human and mouse hematopoietic stem cells	Ocampo et al. (2016)
HP1 beta	Heterochromatin associated protein	Accumulation	Mice and primate tissues	Li et al. (2010)