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. Author manuscript; available in PMC: 2023 Aug 3.
Published in final edited form as: Neuron. 2022 Aug 3;110(15):2363–2385. doi: 10.1016/j.neuron.2022.06.024

Figure 7. Modulation of neural co-firing and neural activity propagation with low-frequency alternating current stimulation (ACS).

Figure 7.

A. Failure of neural activity propagation in perilesional cortex (PLC). Poor propagation is associated with variable neural patterns and variable task performance.

B. ACS at 3Hz can boost propagation through boosting neural co-firing at phases of stimulation. Increased co-firing at the start of a RTG neural pattern can boost propagation through the weakened network.

C. ACS at ~3Hz may match sub movement rhythmicity, enabling distinct subcomponents of a longer movement to benefit from improved neural co-firing associated with ACS phase.

D. General proposal that ACS can restore phasic network excitability and allow improved patterning of muscle activity.