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. Author manuscript; available in PMC: 2023 Aug 3.
Published in final edited form as: Neuron. 2022 Aug 3;110(15):2363–2385. doi: 10.1016/j.neuron.2022.06.024

Figure 9. Framework of therapies.

Figure 9.

Top row illustrates circuits involved in movement control along with neuromodulators that can change circuit properties. Also shown is a model for early patterning of activity as well as a late (recovered) activity patterns. The traces highlight single-trial examples. The DA trace represent both tonic and phasic patterns. Rehabilitation is represented as a phenomenon that occurs at the level of single trials, single sessions and across sessions.

DA=dopamine, NE=norepinephrine, Ach=acetylcholine. E-I=Excitatory-Inhibitory