. 2022 Jul 27;7(31):27550–27559. doi: 10.1021/acsomega.2c03029

Table 1. Concentrations of Compounds in the Plasma and Brains of Rats after Oral Dosing (2 mg/kg) and the Brain-to-Plasma Ratios Derived from These Values^a.

compound	C_max (plasma)	C_max (brain)	C_max (brain/plasma)	AUC 24 h (plasma)	AUC 24 h (brain)	AUC 24 h (brain/plasma)
KRM-II-81	1831.5	594.2	0.32	3589.3	2689.5	0.77
KRM-II-81·HCl	1319.5	689.1	0.52	2662.5	2660.0	1.00

Concentrations are in nM.

Table 1. Concentrations of Compounds in the Plasma and Brains of Rats after Oral Dosing (2 mg/kg) and the Brain-to-Plasma Ratios Derived from These Valuesa.